Transformation of a prefabricated hydroxyapatite/osteogenic protein-1 implant into a vascularised pedicled bone flap in the human chest

被引：78

作者：

Heliotis, M

Lavery, KM

Ripamonti, U

Tsiridis, E

di Silvio, L

机构：

[1] Queen Victoria Hosp, Dept Maxillofacial Surg, E Grinstead RH19 3DZ, W Sussex, England

[2] Univ Witwatersrand, MRC, Bone Res Unit, Johannesburg, South Africa

[3] Royal Devon & Exeter Hosp, Princess Elizabeth Orthopaed Ctr, Exeter EX2 5DW, Devon, England

[4] Kings Coll London, Med & Dent Inst, Guys Kings & St Thomas Hosp, London, England

来源：

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | 2006年 / 35卷 / 03期

关键词：

OP-1; hydroxyapatite; prefabricated implant; vascularised bone graft; mandibular reconstruction; human;

D O I：

10.1016/j.ijom.2005.07.013

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

We describe the intramuscular transformation of a hydroxyapatite/osteogenic protein-1 (HA/OP-1) composite implant, into a vascularised pedicled bone flap useful for reconstruction of a hemi-mandible. Extraskeletal induction of a bone flap for transplantation was achieved without the addition of harvested bone, bone marrow, or stem cells. Five months after apparent clinical success, an MRSA infection of the graft led to its failure. The background to ectopically induced bone flaps is introduced, with our experience in a human case presented. The results from this emerging biotechnology are discussed in the light of limited human clinical experience.

引用

页码：265 / 269

页数：5

共 21 条

[1] Prefabricated vascularized bone flap: A tissue transformation technique for bone reconstruction [J].