Catalytic hydroxylation of steroids by cytochrome P-450 mimics. Hydroxylation at C-9 with novel catalysts and steroid substrates

被引:37
作者
Breslow, R [1 ]
Yan, JM [1 ]
Belvedere, S [1 ]
机构
[1] Columbia Univ, Dept Chem, New York, NY 10027 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
D O I
10.1016/S0040-4039(01)02142-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Double binding of a steroid substrate to our previously described mimic of the cytochrome P-450 enzymes hydroxylates carbon 9 of the steroid, but with a second significant product. The geometry has been adjusted with new catalysts that show high selectivity and excellent turnover for the C-9 hydroxylation. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:363 / 365
页数:3
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