Geometrically directed selective steroid hydroxylation with high turnover by a fluorinated artificial cytochrome P-450

被引：68

作者：

Breslow, R ^{[1
]}

Gabriele, B ^{[1
]}

Yang, J ^{[1
]}

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 19期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(98)00425-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metalloporphyrin has been synthesized carrying a beta-cyclodextrin group on tetrafluorophenyl rings at the four meso positions of the porphyrin. It performs the selective hydroxylation of an androstanediol derivative with complete positional selectivity and 187 turnovers. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：2887 / 2890

页数：4

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