A Call for Systematic Research on Solute Carriers

被引：500

作者：

Cesar-Razquin, Adrian ^{[1
]}

Snijder, Berend ^{[1
]}

Frappier-Brinton, Tristan ^{[2
]}

Isserlin, Ruth ^{[3
]}

Gyimesi, Gergely ^{[4
,5
]}

Bai, Xiaoyun ^{[6
]}

Reithmeier, Reinhart A. ^{[6
]}

Hepworth, David ^{[7
]}

Hediger, Matthias A. ^{[4
,5
]}

Edwards, Aled M. ^{[2
]}

Superti-Furga, Giulio ^{[1
,8
]}

机构：

[1] Austrian Acad Sci, CeMM Res Ctr Mol Med, A-1090 Vienna, Austria

[2] Univ Toronto, Struct Genom Consortium, Toronto, ON M5G 1L7, Canada

[3] Univ Toronto, Donnelly Ctr, Toronto, ON M5S 3E1, Canada

[4] Univ Bern, NCCR TransCure, Inst Biochem & Mol Med, CH-3012 Bern, Switzerland

[5] Univ Bern, NCCR TransCure, Swiss Natl Ctr Competence Res, CH-3012 Bern, Switzerland

[6] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada

[7] Pfizer Worldwide Res & Dev, Worldwide Med Chem, Cambridge, MA 02139 USA

[8] Med Univ Vienna, Ctr Physiol & Pharmacol, A-1090 Vienna, Austria

来源：

CELL | 2015年 / 162卷 / 03期

基金：

欧洲研究理事会; 英国惠康基金; 巴西圣保罗研究基金会; 瑞士国家科学基金会;

关键词：

GENE-COEXPRESSION NETWORK; CRYO-EM STRUCTURE; DRUG DISCOVERY; HUMAN-CELLS; MEMBRANE-PROTEINS; BLOOD METABOLITES; MASS-SPECTROMETRY; CRYSTAL-STRUCTURE; HUMAN PROTEOME; TRANSPORTER;

D O I：

10.1016/j.cell.2015.07.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Solute carrier (SLC) membrane transport proteins control essential physiological functions, including nutrient uptake, ion transport, and waste removal. SLCs interact with several important drugs, and a quarter of the more than 400 SLC genes are associated with human diseases. Yet, compared to other gene families of similar stature, SLCs are relatively understudied. The time is right for a systematic attack on SLC structure, specificity, and function, taking into account kinship and expression, as well as the dependencies that arise from the common metabolic space.

引用

页码：478 / 487

页数：10

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