Dapson in Heterocyclic Chemistry, Part III: Synthesis, Antimicrobial, and Antitumor Activities of Some New Bisheterocyclic Compounds Containing Biologically Active Diphenylsulfone Moiety

被引：12

作者：

Ghorab, M. M. ^{[1
]}

Amin, N. E. ^{[1
]}

El Gaby, M. S. A. ^{[2
]}

Taha, N. M. H. ^{[3
]}

Shehab, M. A. ^{[4
]}

Faker, I. M. I. ^{[4
]}

机构：

[1] Natl Ctr Radiat Res & Technol, Dept Drug Radiat Res, Cairo, Egypt

[2] Al Azhar Univ, Fac Sci Boys, Dept Organ Chem, Cairo, Egypt

[3] Al Azhar Univ, Fac Sci Girls, Dept Organ Chem, Cairo, Egypt

[4] Natl Res Ctr, Appl Organ Chem Dept, Cairo, Egypt

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2008年 / 183卷 / 12期

关键词：

Antimicrobial and antitumor activities; biscompounds having diphenylsulfone moiety;

D O I：

10.1080/10426500802505440

中图分类号：

O61 [无机化学];

学科分类号：

070301 [无机化学]; 081704 [应用化学];

摘要：

The key intermediate diisothiocyanate 2 was allowed to react with 5-amino-3-methyl-pyrazole-4-carbonitrile 3, ethyl 5-amino-1-phenyl-pyrazole-4-carboxylate 6, 2-amino-tetrahydrobenzo[b]thiophene-3-car-bonitrile 9, ethyl-2-amino-tetra-hydrobenzo[b]thiophene-3-carboxylate 12, and/or 1,2,4-triazole 15 to give the corresponding biscompounds 4, 5, 7, 8, 10, 11, 13, 14, and 16, respectively. The structure of the synthesized compounds was elucidated by elemental analyses and spectral data. Some of the prepared compounds were tested for their antimicrobial and antitumor activities.

引用

页码：2918 / 2928

页数：11

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