O-antigen repeat number in Salmonella enterica serovar Enteritidis is important for egg contamination, colonisation of the chicken reproductive tract and survival in egg albumen

被引：19

作者：

Coward, Chris ^{[1
]}

Sait, Leanne ^{[2
]}

Cogan, Tristan ^{[2
]}

Humphrey, Tom J. ^{[3
]}

Maskell, Duncan J. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Vet Med, Cambridge CB3 0ES, England

[2] Univ Bristol, Sch Vet Sci, Bristol BS18 7DU, Avon, England

[3] Univ Liverpool, Wirral L64 7TE, Merseyside, England

来源：

FEMS MICROBIOLOGY LETTERS | 2013年 / 343卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

lipopolysaccharide; avian; egg; oviduct; ovary; CHAIN-LENGTH; LIPOPOLYSACCHARIDE; TYPHIMURIUM; IDENTIFICATION; RESISTANCE; VIRULENCE; INVASION; GENES; CELLS; HENS;

D O I：

10.1111/1574-6968.12143

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Salmonella enterica serovar Enteritidis is a major cause of human gastrointestinal disease, infection being due in large part to consumption of contaminated eggs. The lipopolysaccharide (LPS) of Salmonella is known to play a role in colonisation of the host and survival in hostile conditions including egg albumen. We investigated the contribution of LPS O-antigen length to colonisation of the reproductive tract of laying hens, contamination of eggs and survival in albumen. We show that expression of very-long O-antigen is essential for contamination of eggs, probably as a consequence of enhanced reproductive tract colonisation and survival in the forming egg.

引用

页码：169 / 176

页数：8

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