Highly enantioselective zinc/binol-catalyzed alkynylation of N-sulfonyl aldimines

被引：67

作者：

Blay, Gonzalo ^{[1
]}

Cardona, Luz ^{[1
]}

Climent, Estela ^{[1
]}

Pedro, Jose R. ^{[1
]}

机构：

[1] Univ Valencia, Dept Quim Organ, Fac Quim, E-46100 Valencia, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 30期

关键词：

alkynes; amines; arene ligands; synthetic methods; zinc;

D O I：

10.1002/anie.200801020

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) It all adds up with zinc: Terminal alkynes react with N-tosyl aldimines in the presence of dimethylzinc and binol-type ligands to give to N-tosyl-protected propargylic amines with good yields and high enantiomeric excesses (up to more than 99%; see scheme). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5593 / 5596

页数：4

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