Mandelamide-zinc-catalyzed enantioselective alkyne addition to heteroaromatic aldehydes

被引：39

作者：

Blay, Gonzalo ^{[1
]}

Fernandez, Isabel ^{[1
]}

Marco-Aleixandre, Alicia ^{[1
]}

Pedro, Jose R. ^{[1
]}

机构：

[1] Univ Valencia, Fac Quim, Dept Quim Organ, E-46100 Burjassot, Spain

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 17期

关键词：

D O I：

10.1021/jo0610255

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The (S,S)- mandelamide III catalyzes the additions of both aryl- and alkylalkynylzinc reagents to heteroaromatic aldehydes with good yields and enantioselectivities up to 92%. This catalyst is easily prepared in a one-step procedure, and both enantiomers are available. Unlike most other described methods, using this catalyst does not require the addition of Ti((OPr)-Pr-i)(4).

引用

页码：6674 / 6677

页数：4

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