Getting RNA and Protein in Phase

被引：384

作者：

Weber, Stephanie C. ^{[1
]}

Brangwynne, Clifford P. ^{[1
]}

机构：

[1] Princeton Univ, Dept Chem & Biol Engn, Princeton, NJ 08544 USA

来源：

CELL | 2012年 / 149卷 / 06期

关键词：

CELL-FREE FORMATION; BINDING PROTEINS; GRANULES; HYDROGELS; BODIES; FORM;

D O I：

10.1016/j.cell.2012.05.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nonmembrane-bound organelles such as RNA granules behave like dynamic droplets, but the molecular details of their assembly are poorly understood. Several recent papers identify structural features that drive granule assembly, shedding light on how phase transitions functionally organize the cell and may lead to pathological protein aggregation.

引用

页码：1188 / 1191

页数：4

共 20 条

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