How to extinguish lymphocyte activation, immunotyrosine-based inhibition motif (ITIM)-bearing molecules a solution?

被引：5

作者：

Blery, M ^{[1
]}

Vivier, E ^{[1
]}

机构：

[1] Ctr Immunol Marseille Luminy, F-13288 Marseille 9, France

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 1999年 / 37卷 / 03期

关键词：

ImmunoTyrosine-based inhibition motif (ITIM); SHP-1; SHIP; phosphatases; lymphocyte regulation; inhibition;

D O I：

10.1515/CCLM.1999.035

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

ITIM-bearing molecules represent a novel family of inhibitory receptors expressed widely through the hematopoietic compartment. These molecules share certain features such as the presence in their intracytoplasmic domain of the so-called motif ITIM (Immuno-Tyrosine-based Inhibition Motif). These molecules are able to recruit phosphatases on their phosphorylated ITIM and thus mediate a localized inhibition of the transduction pathways. The molecular basis of this inhibitory pathway is discussed below.

引用

页码：187 / 191

页数：5

共 57 条

[41] SUPERANTIGEN-DEPENDENT, CELL-MEDIATED CYTOTOXICITY INHIBITED BY MHC CLASS-I RECEPTORS ON T-LYMPHOCYTES [J].

PHILLIPS, JH ;

GUMPERZ, JE ;

PARHAM, P ;

LANIER, LL .

SCIENCE, 1995, 268 (5209) :403-405

[42] Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling [J].

Plas, DR ;

Johnson, R ;

Pingel, JT ;

Matthews, RJ ;

Dalton, M ;

Roy, G ;

Chan, AC ;

Thomas, ML .

SCIENCE, 1996, 272 (5265) :1173-1176

[43] POTENT STIMULATION OF SH-PTP2 PHOSPHATASE-ACTIVITY BY SIMULTANEOUS OCCUPANCY OF BOTH SH2 DOMAINS [J].

PLUSKEY, S ;

WANDLESS, TJ ;

WALSH, CT ;

SHOELSON, SE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (07) :2897-2900

[44] Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: Structural evidence for new stimulatory and inhibitory pathways [J].

Samaridis, J ;

Colonna, M .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (03) :660-665

[45] Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3) Tec kinase-dependent calcium signaling pathway:: a target for SHIP-mediated inhibitory signals [J].

Scharenberg, AM ;

El-Hillal, O ;

Fruman, DA ;

Beitz, LO ;

Li, ZM ;

Lin, SQ ;

Gout, I ;

Cantley, LC ;

Rawlings, DJ ;

Kinet, JP .

EMBO JOURNAL, 1998, 17 (07) :1961-1972

[46] Regulation of B cell signal transduction by SH2-containing protein-tyrosine phosphatases [J].

Siminovitch, KA ;

Neel, BG .

SEMINARS IN IMMUNOLOGY, 1998, 10 (04) :329-347

[47] Growth hormone regulation of SIRP and SHP-2 tyrosyl phosphorylation and association [J].

Stofega, MR ;

Wang, HY ;

Ullrich, A ;

Carter-Su, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (12) :7112-7117

[48] The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression [J].

Symes, A ;

Stahl, N ;

Reeves, SA ;

Farruggella, T ;

Servidei, T ;

Gearan, T ;

Yancopoulos, G ;

Fink, JS .

CURRENT BIOLOGY, 1997, 7 (09) :697-700

[49] Identification of major binding proteins and substrates for the SH2-containing protein tyrosine phosphatase SHP-1 in macrophages [J].

Timms, JF ;

Carlberg, K ;

Gu, HH ;

Chen, HY ;

Kamatkar, S ;

Nadler, MJS ;

Rohrschneider, LR ;

Neel, BG .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (07) :3838-3850

[50] Signalling through the lipid products of phosphoinositide-3-OH kinase [J].

Toker, A ;

Cantley, LC .

NATURE, 1997, 387 (6634) :673-676

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