A Role for the ESCRT System in Cell Division in Archaea

被引：259

作者：

Samson, Rachel Y. ^{[1
]}

Obita, Takayuki ^{[2
]}

Freund, Stefan M. ^{[3
]}

Williams, Roger L. ^{[2
]}

Bell, Stephen D. ^{[1
]}

机构：

[1] MRC, Canc Cell Unit, Cambridge CB2 0XZ, England

[2] MRC, Mol Biol Lab, Cambridge CB2 0QH, England

[3] MRC, Ctr Prot Engn, Cambridge CB2 0QH, England

来源：

SCIENCE | 2008年 / 322卷 / 5908期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1126/science.1165322

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Archaea are prokaryotic organisms that lack endomembrane structures. However, a number of hyperthermophilic members of the Kingdom Crenarchaea, including members of the Sulfolobus genus, encode homologs of the eukaryotic endosomal sorting system components Vps4 and ESCRT- III ( endosomal sorting complex required for transport- III). We found that Sulfolobus ESCRT- III and Vps4 homologs underwent regulation of their expression during the cell cycle. The proteins interacted and we established the structural basis of this interaction. Furthermore, these proteins specifically localized to the mid- cell during cell division. Overexpression of a catalytically inactive mutant Vps4 in Sulfolobus resulted in the accumulation of enlarged cells, indicative of failed cell division. Thus, the archaeal ESCRT system plays a key role in cell division.

引用

页码：1710 / 1713

页数：4

共 21 条

[1] A dynamic bacterial cytoskeleton
Carballido-Löpez, R
Errington, J
[J]. TRENDS IN CELL BIOLOGY, 2003, 13 (11) : 577 - 583
[2] Parallels between cytokinesis and retroviral budding: A role for the ESCRT machinery
Carlton, Jez G.
Martin-Serrano, Juan
[J]. SCIENCE, 2007, 316 (5833) : 1908 - 1912
[3] Chromosome replication dynamics in the archaeon Sulfolobus acidocaldarius
Duggin, Iain G.
McCallum, Simon A.
Bell, Stephen D.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (43) : 16737 - 16742
[4] The push and pull of the bacterial cytoskeleton
Dye, Natalie A.
Shapiro, Lucy
[J]. TRENDS IN CELL BIOLOGY, 2007, 17 (05) : 239 - 245
[5] Beyond Tsg101: the role of Alix in 'ESCRTing' HIV-1
Fujii, Ken
Hurley, James H.
Freed, Eric O.
[J]. NATURE REVIEWS MICROBIOLOGY, 2007, 5 (12) : 912 - 916
[6] The Sulfolobus solfataricus AAA protein sso090, a homologue of the eukaryotic ESCRT vps4 ATPase
Hobel, Cedric F. V.
Albers, Sonja V.
Driessen, Arnold J. M.
Lupas, Andrei N.
[J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2008, 36 : 94 - 98
[7] The ESCRT complexes: Structure and mechanism of a membrane-trafficking network
Hurley, James H.
Emr, Scott D.
[J]. ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 2006, 35 : 277 - 298
[8] Archaeal dominance in the mesopelagic zone of the Pacific Ocean
Karner, MB
DeLong, EF
Karl, DM
[J]. NATURE, 2001, 409 (6819) : 507 - 510
[9] Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding
Kieffer, Collin
Skalicky, Jack J.
Morita, Eiji
De Domenico, Ivana
Ward, Diane M.
Kaplan, Jerry
Sundquist, Wesley I.
[J]. DEVELOPMENTAL CELL, 2008, 15 (01) : 62 - 73
[10] Regulation of expression of the arabinose and glucose transporter genes in the thermophilic archaeon Sulfolobus solfataricus
Lubelska, Joanna M.
Jonuscheit, Melanie
Schleper, Christa
Albers, Sonja-Verena
Driessen, Arnold J. M.
[J]. EXTREMOPHILES, 2006, 10 (05) : 383 - 391

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