An intermediate seeks instant gratification

被引：11

作者：

Gruebele, M

机构：

[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Phys, Urbana, IL 61801 USA

[3] Univ Illinois, Ctr Biophys & Computat Biol, Urbana, IL 61801 USA

来源：

NATURE STRUCTURAL BIOLOGY | 2002年 / 9卷 / 03期

关键词：

D O I：

10.1038/nsb0302-154

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phi-value analysis of the four-helix protein Im7 reveals that a folding intermediate with non-native structure rapidly forms en route to the native state, even though the protein topology is very simple. Energetic frustration, at least partially induced by functional constraints, appears to play a significant role.

引用

页码：154 / 155

页数：2

共 10 条

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