A linker for amidines in solid phase synthesis

被引：29

作者：

Roussel, P

Bradley, M

Matthews, I

Kane, P

机构：

[1] UNIV SOUTHAMPTON,DEPT CHEM,SOUTHAMPTON SO17 1BJ,HANTS,ENGLAND

[2] NOVARTIS PHARMACEUT,HORSHAM,W SUSSEX,ENGLAND

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 27期

关键词：

D O I：

10.1016/S0040-4039(97)01013-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A range of linkers for the important amidine pharmacophore, cleavable using acid or light have been developed for use in library synthesis. The utility of these linkers is demonstrated by the solid phase synthesis of the Novartis (ex-Ciba) phase II compound CGS-25019C. (C) 1997 Elsevier Science Ltd.

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收藏

页码：4861 / 4864

页数：4

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