Solid-phase synthesis via N-terminal attachment to the 2-chlorotrityl resin

被引：36

作者：

Hoekstra, WJ

Greco, MN

Yabut, SC

Hulshizer, BL

Maryanoff, BE

机构：

[1] Drug Discovery, R. W. Johnson Pharmaceutical Res. I., Spring House

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 15期

关键词：

D O I：

10.1016/S0040-4039(97)00447-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Connection of a secondary amine to the 2-chlorotrityl resin followed by iterative saponification/coupling sequences provided a basis for generating focused peptidomimetic mini-libraries. (C) 1997 Elsevier Science Ltd.

引用

页码：2629 / 2632

页数：4

共 17 条

[1] REINVESTIGATION OF A MODIFIED HANTZSCH THIAZOLE SYNTHESIS
AGUILAR, E
MEYERS, AI
[J]. TETRAHEDRON LETTERS, 1994, 35 (16) : 2473 - 2476
[2] SYNTHESIS OF PROTECTED PEPTIDE-FRAGMENTS USING SUBSTITUTED TRIPHENYLMETHYL RESINS
BARLOS, K
GATOS, D
KALLITSIS, J
PAPAPHOTIU, G
SOTIRIU, P
YAO, WQ
SCHAFER, W
[J]. TETRAHEDRON LETTERS, 1989, 30 (30) : 3943 - 3946
[3] THE CHIRAL SYNTHESIS OF THIAZOLE AMINO-ACID ENANTIOMERS
BREDENKAMP, MW
HOLZAPFEL, CW
VANZYL, WJ
[J]. SYNTHETIC COMMUNICATIONS, 1990, 20 (15) : 2235 - 2249
[4] ANALOGOUS ORGANIC-SYNTHESIS OF SMALL-COMPOUND LIBRARIES - VALIDATION OF COMBINATORIAL CHEMISTRY IN SMALL-MOLECULE SYNTHESIS
CHEN, CX
RANDALL, LAA
MILLER, RB
JONES, AD
KURTH, MJ
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (06) : 2661 - 2662
[5] Cody D.R., 1994, U.S. Patent, Patent No. [5,324,483, 5324483]
[6] LINKERS FOR COMBINATORIAL CHEMISTRY AND REACTION ANALYSIS USING SOLID-PHASE IN-SITU MASS-SPECTROMETRY
EGNER, BJ
CARDNO, M
BRADLEY, M
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1995, (21) : 2163 - 2164
[7] A SOLID-PHASE CBZ CHLORIDE EQUIVALENT - A NEW MATRIX SPECIFIC LINKER
HAUSKE, JR
DORFF, P
[J]. TETRAHEDRON LETTERS, 1995, 36 (10) : 1589 - 1592
[8] Solid-phase parallel synthesis applied to lead optimization: Discovery of potent analogues of the GPIIb/IIIa antagonist RWJ-50042
Hoekstra, WJ
Maryanoff, BE
AndradeGordon, P
Cohen, JH
Costanzo, MJ
Damiano, BP
Haertlein, BJ
Harris, BD
Kauffman, JA
Keane, PM
McComsey, DF
Villani, FJ
Yabut, SC
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (20) : 2371 - 2376
[9] ADAMANTANE AND NIPECOTIC ACID-DERIVATIVES AS NOVEL BETA-TURN MIMICS
HOEKSTRA, WJ
PRESS, JB
BONNER, MP
ANDRADEGORDON, P
KEANE, PM
DURKIN, KA
LIOTTA, DC
MAYO, KH
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (11) : 1361 - 1364
[10] DESIGN AND EVALUATION OF NONPEPTIDE FIBRINOGEN GAMMA-CHAIN BASED GPIIB/IIIA ANTAGONISTS
HOEKSTRA, WJ
BEAVERS, MP
ANDRADEGORDON, P
EVANGELISTO, MF
KEANE, PM
PRESS, JB
TOMKO, KA
FAN, F
KLOCZEWIAK, M
MAYO, KH
DURKIN, KA
LIOTTA, DC
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (10) : 1582 - 1592

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