Design and application of linked-BINOL chiral ligands in bifunctional asymmetric catalysis

被引：285

作者：

Shibasaki, M ^{[1
]}

Matsunaga, S ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

CHEMICAL SOCIETY REVIEWS | 2006年 / 35卷 / 03期

关键词：

D O I：

10.1039/b506346a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The design and application of linked-BINOLs investigated in our group are reviewed. Linked-BINOLs are a kind of semi-crown ether, thus they are flexible and applicable to metals having various ionic radii (Ga3+, Li+, Zn2+, In3+, La3+, and Y3+). The flexible linker segment, containing a coordinative heteroatom, has a crucial role in the construction of a unique and effective chiral environment that is not accessible from BINOL itself. Applications of linked-BINOLs to an epoxide opening reaction, Michael reactions, a direct aldol reaction, direct Michael reactions of a hydroxyketone, and direct Mannich-type reactions of hydroxyketones and N-acylpyrrole are described.

引用

页码：269 / 279

页数：11

共 38 条

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