Emerging regulation and functions of autophagy

被引：1001

作者：

Boya, Patricia ^{[1
]}

Reggiori, Fulvio ^{[2
,3
]}

Codogno, Patrice ^{[4
]}

机构：

[1] CSIC, Ctr Invest Biol, Dept Cellular & Mol Biol, Madrid 28040, Spain

[2] Univ Med Ctr Utrecht, Dept Cell Biol, NL-3584 CX Utrecht, Netherlands

[3] Univ Med Ctr Utrecht, Inst Biomembranes, NL-3584 CX Utrecht, Netherlands

[4] Univ Paris 05, INSERM U845, Necker Growth & Signaling Res Ctr, F-75014 Paris, France

来源：

NATURE CELL BIOLOGY | 2013年 / 15卷 / 07期

关键词：

SELECTIVE AUTOPHAGY; UNCONVENTIONAL SECRETION; ENDOPLASMIC-RETICULUM; INDEPENDENTLY TARGET; AEROBIC GLYCOLYSIS; MEDIATED CLEAVAGE; ATG PROTEINS; TUMOR-GROWTH; CELL-DEATH; PHOSPHORYLATION;

D O I：

10.1038/ncb2788

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autophagy maintains cell, tissue and organism homeostasis through degradation. Complex post-translational modulation of the Atg (autophagy-related) proteins adds additional entry points for crosstalk with other cellular processes and helps define cell-type-specific regulations of autophagy. Beyond the simplistic view of a process exclusively dedicated to the turnover of cellular components, recent data have uncovered unexpected functions for autophagy and the autophagy-related genes, such as regulation of metabolism, membrane transport and modulation of host defenses - indicating the novel frontiers lying ahead.

引用

页码：713 / 720

页数：8

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