Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21WAF1/CIP1

被引：38

作者：

Kim, MJ

Yoo, YA

Kim, HJ

Kang, S

Kim, YG

Kim, JS

Yoo, YD ^{[1
]}

机构：

[1] Korea Univ, Coll Med, Grad Sch Med, Seoul 136705, South Korea

[2] Korea Univ, Sch Life Sci & Biotechnol, Seoul 136705, South Korea

[3] Yonsei Univ, Dept Internal Med, Coll Med, Seoul 135270, South Korea

[4] Korea Univ, Coll Med, Div Brain Korea 21 Program Biomed Sci, Seoul 136705, South Korea

[5] Korea Univ, Coll Med, Dept Internal Med, Seoul 136705, South Korea

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 338卷 / 02期

关键词：

MRPL41; p21(WAF1/CIP1); serum starvation; p53; cell cycle; p27 (Kip1);

D O I：

10.1016/j.bbrc.2005.10.064

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27(Kip1) in the absence of p53. This study found that MRPL41 mediates the p21(WAF1/CIP1)-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21(WAF1/CIP1) and P27(Kip1) levels under the growth inhibitory conditions. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：1179 / 1184

页数：6

共 32 条

[31] AP2 inhibits cancer cell growth and activates p21(WAF1)/(CIP1) expression [J].