Hepatocyte growth factor concentrations are elevated in peritoneal fluid of women with endometriosis

被引：42

作者：

Osuga, Y ^{[1
]}

Tsutsumi, O ^{[1
]}

Okagaki, R ^{[1
]}

Takai, Y ^{[1
]}

Fujimoto, A ^{[1
]}

Suenaga, A ^{[1
]}

Maruyama, M ^{[1
]}

Momoeda, M ^{[1
]}

Yano, T ^{[1
]}

Taketani, Y ^{[1
]}

机构：

[1] Univ Tokyo, Dept Obstet & Gynecol, Tokyo 1138655, Japan

来源：

HUMAN REPRODUCTION | 1999年 / 14卷 / 06期

关键词：

endometriosis; hepatocyte growth factor; peritoneal fluid;

D O I：

10.1093/humrep/14.6.1611

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The concentrations of hepatocyte growth factor (HGF) in peritoneal fluid (PF) from women with endometriosis (n = 36) and without endometriosis (n = 40) were measured. All of the PF samples examined contained detectable concentrations of HGF. The HGF concentrations in PF from women with stage III/IV endometriosis (0.906 ng/ml, 0.561-1.185; median, interquartile range) were significantly higher (P < 0.0001) than those from women without endometriosis (0.315 ng/ml, 0.251-0.472), The HGF concentrations from women with stage I/II endometriosis (0.417 ng/ml, 0.310-1.023) appeared to be intermediate. There were no apparent variations detected among the HGF concentrations in women in the follicular or luteal phases regardless of the presence of endometriosis. Interestingly, HGF concentrations in PF from women on gonadotrophin releasing hormone analogues, independent of the presence of endometriosis, were comparable with those from untreated women. Given the known mitogenic property of HGF in human endometrial cells, these results suggest that HGF might play a role in the progression of endometriosis.

引用

页码：1611 / 1613

页数：3

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