Histone acetylation in signal transduction by growth regulatory signals

被引：22

作者：

Magnaghi-Jaulin, L ^{[1
]}

Ait-Si-Ali, S ^{[1
]}

Harel-Bellan, A ^{[1
]}

机构：

[1] IRC, CNRS, UPR 9079, F-94800 Villejuif, France

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 1999年 / 10卷 / 02期

关键词：

CBP; chromatin; E2F; histone acetylation; Rb;

D O I：

10.1006/scdb.1999.0301

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell fate is determined by extracellular signals which are transmitted to the nucleus and result in the transcriptional regulation of specific subsets of genes. Transcriptional regulation has been recently linked to enzymatic activities which are able to acetylate or deacetylate core histone tails. A number of transcriptional co-regulators are histone acetyltransferases or histone deacetylases. Here, we discuss the involvement of these enzymes in critical steps of cell proliferation or cell differentiation control.

引用

页码：197 / 203

页数：7

共 107 条

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