Chromosome 14q32 translocations involving the immunoglobulin heavy chain locus in chronic lymphocytic leukaemia identify a disease subset with poor prognosis

被引：65

作者：

Cavazzini, Francesco ^{[1
]}

Hernandez, Jose Angel ^{[2
]}

Gozzetti, Alessandro ^{[3
]}

Rossi, Antonella Russo ^{[1
]}

De Angeli, Cristiano ^{[1
]}

Tiseo, Ruana ^{[1
]}

Bardi, Antonella ^{[1
]}

Tammiso, Elisa ^{[1
]}

Crupi, Rosaria ^{[3
]}

Lenoci, Maria Pia ^{[3
]}

Forconi, Francesco

Lauria, Francesco

Marasca, Roberto ^{[4
]}

Maffei, Rossana ^{[4
]}

Torelli, Giuseppe ^{[4
]}

Gonzalez, Marcos ^{[5
,6
]}

Martin-Jimenez, Patricia ^{[5
,6
]}

Hernandez, Jesus Maria ^{[5
,6
]}

Rigolin, Gian Matteo ^{[1
]}

Cuneo, Antonio ^{[1
]}

机构：

[1] Univ Ferrara, Sect Haematol, Dept Biomed Sci & Adv Therapies, I-44100 Ferrara, Italy

[2] Hosp Fuenlabrada, Madrid, Spain

[3] Univ Siena, Dept Med & Immunol Sci, Div Haematol & Transplants, I-53100 Siena, Italy

[4] Univ Modena, Dept Haematol & Oncol, I-41100 Modena, Italy

[5] Univ Salamanca, CSIC, Hosp Univ Salamanca, Hematol Serv, E-37008 Salamanca, Spain

[6] Univ Salamanca, CSIC, Ctr Invest Canc, E-37008 Salamanca, Spain

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2008年 / 142卷 / 04期

关键词：

chronic lymphocytic leukaemia; cytogenetics; prognostic factors; IgH; FISH;

D O I：

10.1111/j.1365-2141.2008.07227.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immunophenotypic studies, fluorescence in situ hybridization (FISH) and conventional karyotyping were used to define the clinicobiological significance of 14q32 translocations involving the immunoglobulin gene locus (14q32/IGH) in 252 chronic lymphocytic leukaemia (CLL) patients. The following regions were studied: 13q14, centromere 12, 6q21; 11q22/ATM; 17p13/TP53, 14q32/IGH. Patients were classified as group 1 (favourable, i.e. 13q-single or normal), group 2 (intermediate risk, i.e. +12, 6q-, 1-2 anomalies), group 3 (unfavourable, i.e. 17p-, 11q-, complex karyotype), or group 4 (14q32/IGH translocation). Endpoints were treatment-free survival (TFS) and overall survival (OS). One hundred and ten patients were included in group 1, 99 in group 2, 25 in group 3 and 18 in group 4. 14q32/IGH translocation partners were identified in eight cases (BCL2 in five cases, BCL11A, CCND3 and CDK6 in one case each). group 4 showed shorter TFS versus groups 2 and 1 (25% patients treated at 2 months vs. 12 (P = 0.02) and 20 months (P = 0.002), respectively) and shorter OS (25% patients dead at 18 months versus 50 (P = 0.0003) and > 60 months (P < 0.0001) respectively. The 14q32/IGH translocation maintained prognostic significance at multivariate analysis on TFS (P = 0.025) and OS (P < 0.001), along with advanced stage and CD38(+). These findings show that the 14q32/IGH translocation predicts for an unfavourable outcome in CLL and that this cytogenetic subset might be included as a separate entity in a hierarchical cytogenetic classification of CLL.

引用

页码：529 / 537

页数：9

共 43 条

[41] Cyclin D3 is a target gene of t(6;14)(p21.1;q32.3) of mature B-cell malignancies [J].