Highly efficient and mild synthesis of variously 5-substituted-4-carbaldehyde-1,2,3-triazole derivatives

被引：66

作者：

Journet, M ^{[1
]}

Cai, DW ^{[1
]}

Kowal, JJ ^{[1
]}

Larsen, RD ^{[1
]}

机构：

[1] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 52期

关键词：

D O I：

10.1016/S0040-4039(01)01923-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of variously 5-substittited-4-carbaldehyde-1,2,3-triazole derivatives 2 was accomplished by reacting sodium azide with alpha,beta -acetylenic aldehydes I in DMSO at room temperature. Therefore. the reaction remains basic avoiding the generation of the hazardous explosive HN3, resulting in a safe process. This mild and general reaction was instantaneous and was essentially quantitative. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：9117 / 9118

页数：2

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