Highly efficient synthesis of α,β-acetylenic aldehydes from terminal alkynes using DMF as the formylating reagent.

被引：91

作者：

Journet, M ^{[1
]}

Cai, DW ^{[1
]}

DiMichele, LM ^{[1
]}

Larsen, RD ^{[1
]}

机构：

[1] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 36期

关键词：

D O I：

10.1016/S0040-4039(98)01352-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The formylation of lithium acetylides with DMF led to alpha,beta-acetylenic aldehydes in excellent yields (>94%). A reverse quench into a phosphate buffer (10% aqueous KH2PO4 ,4 equiv) proved ro he the key for this high-yielding reaction. (C) 1998 Elsevier Science Ltd. All rights reserved.

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收藏

页码：6427 / 6428

页数：2

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