Activities of polymyxin B and cecropin A-melittin peptide CA(1-8)M(1-18) against a multiresistant strain of Acinetobacter baumannii

被引：48

作者：

Saugar, JM

Alarcón, T

López-Hernández, S

López-Brea, M

Andreu, D

Rivas, L

机构：

[1] CSIC, Ctr Invest Biol, E-28006 Madrid, Spain

[2] Hosp Univ Princesa, Microbiol Serv, E-28006 Madrid, Spain

[3] Univ Barcelona, Dept Organ Chem, E-08028 Barcelona, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 03期

关键词：

D O I：

10.1128/AAC.46.3.875-878.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Polymyxin B (PXB) and the cecropin A-melittin hybrid CA(1-8)M(1-18) (KWKLFKKIGIGAVLKVLTTG LPALIS-NH2) were compared for antibiotic activity on reference and multiresistant Acinetobacter baumannii strains. Significant differences for both peptides were observed on their inner membrane interaction and inhibition by environmental factors, supporting the use of CA(1-8)M(1-18) as a potential alternative to PXB against Acinetobacter.

引用

收藏

页码：875 / 878

页数：4

相关论文

共 20 条

[1]

Alarcon T, 2001, Rev Esp Quimioter, V14, P184

[2] Acinetobacter spp, as nosocomial pathogens: Microbiological, clinical, and epidemiological features [J].

BergogneBerezin, E ;

Towner, KJ .

CLINICAL MICROBIOLOGY REVIEWS, 1996, 9 (02) :148-+

[3] ANTIBACTERIAL AND ANTIMALARIAL PROPERTIES OF PEPTIDES THAT ARE CECROPIN-MELITTIN HYBRIDS [J].

BOMAN, HG ;

WADE, D ;

BOMAN, IA ;

WAHLIN, B ;

MERRIFIELD, RB .

FEBS LETTERS, 1989, 259 (01) :103-106

[4] Stages of polymyxin B interaction with the Escherichia coli cell envelope [J].

Daugelavicius, R ;

Bakiené, E ;

Bamford, DH .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (11) :2969-2978

[5] Polymyxin B sulfate and colistin: Old antibiotics for emerging multiresistant gram-negative bacteria [J].

Evans, ME ;

Feola, DJ ;

Rapp, RP .

ANNALS OF PHARMACOTHERAPY, 1999, 33 (09) :960-967

[6] Salt-resistant alpha-helical cationic antimicrobial peptides [J].

Friedrich, C ;

Scott, MG ;

Karunaratne, N ;

Yan, H ;

Hancock, REW .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (07) :1542-1548

[7] Comparative activities of polycationic peptides and clinically used antimicrobial agents against multidrug-resistant nosocomial isolates of Acinetobacter baumannii [J].

Giacometti, A ;

Cirioni, O ;

Del Prete, MS ;

Barchiesi, F ;

Paggi, AM ;

Petrelli, E ;

Scalise, G .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 46 (05) :807-810

[8] Antiendotoxin activity of cationic peptide antimicrobial agents [J].

Gough, M ;

Hancock, REW ;

Kelly, NM .

INFECTION AND IMMUNITY, 1996, 64 (12) :4922-4927

[9] INHIBITION OF ESCHERICHIA-COLI GROWTH AND RESPIRATION BY POLYMYXIN-B COVALENTLY ATTACHED TO AGAROSE BEADS [J].

LAPORTE, DC ;

ROSENTHAL, KS ;

STORM, DR .

BIOCHEMISTRY, 1977, 16 (08) :1642-1648

[10] INTERACTION OF POLYCATIONIC ANTIBIOTICS WITH PSEUDOMONAS-AERUGINOSA LIPOPOLYSACCHARIDE AND LIPID-A STUDIED BY USING DANSYL-POLYMYXIN [J].

MOORE, RA ;

BATES, NC ;

HANCOCK, REW .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 29 (03) :496-500