Activities of polymyxin B and cecropin A-melittin peptide CA(1-8)M(1-18) against a multiresistant strain of Acinetobacter baumannii

被引：48

作者：

Saugar, JM

Alarcón, T

López-Hernández, S

López-Brea, M

Andreu, D

Rivas, L

机构：

[1] CSIC, Ctr Invest Biol, E-28006 Madrid, Spain

[2] Hosp Univ Princesa, Microbiol Serv, E-28006 Madrid, Spain

[3] Univ Barcelona, Dept Organ Chem, E-08028 Barcelona, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 03期

关键词：

D O I：

10.1128/AAC.46.3.875-878.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Polymyxin B (PXB) and the cecropin A-melittin hybrid CA(1-8)M(1-18) (KWKLFKKIGIGAVLKVLTTG LPALIS-NH2) were compared for antibiotic activity on reference and multiresistant Acinetobacter baumannii strains. Significant differences for both peptides were observed on their inner membrane interaction and inhibition by environmental factors, supporting the use of CA(1-8)M(1-18) as a potential alternative to PXB against Acinetobacter.

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页码：875 / 878

页数：4

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