Selective binding of Borrelia burgdorferi OspE paralogs to factor H and serum proteins from diverse animals:: Possible expansion of the role of OspE in Lyme disease pathogenesis

被引：55

作者：

Hovis, KM

Tran, E

Sundy, CM

Buckles, E

McDowell, JV

Marconi, RT

机构：

[1] Virginia Commonwealth Univ, Med Coll Virginia, Dept Microbiol & Immunol, Richmond, VA 23298 USA

[2] Virginia Commonwealth Univ, Med Coll Virginia, Ctr Study Biol Complex, Richmond, VA 23298 USA

来源：

INFECTION AND IMMUNITY | 2006年 / 74卷 / 03期

关键词：

D O I：

10.1128/IAI.74.3.1967-1972.2006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The binding of Borrelia burgdorferi OspE, OspF, and family 163 (Elp) proteins to factor H/factor H-like protein 1 (FHL-1) and other serum proteins from different animals was assessed. OspE paralogs bound factor H and unidentified serum proteins from a subset of animals, while OspF and Elp proteins did not. These data advance our understanding of factor H binding, the host range of the Lyme spirochetes, and the expanding role of OspE in pathogenesis.

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页码：1967 / 1972

页数：6

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