Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes

被引：459

作者：

Naik, Shalin H. ^{[1
]}

Metcalf, Donald

Van Nieuwenhuijze, Annemarie

Wicks, Ian

Wu, Li

O'Keeffe, Meredith

Shortman, Ken

机构：

[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

[2] Cooperat Res Ctr Vaccine Technol, Parkville, Vic 3050, Australia

[3] Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia

来源：

NATURE IMMUNOLOGY | 2006年 / 7卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/ni1340

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immediate precursors of the many subtypes of dendritic cells (DCs) remain obscure. Here we purified a splenic precursor population that produced all splenic CD8(+) and CD8(-) conventional DCs (cDCs) but not plasmacytoid DCs or other lineages. This 'pre-cDC' population included cells 'precommitted' to form either CD8(+) or CD8(-) cDCs. The pre-cDCs, which comprised 0.05% of splenocytes, expressed a CD11c(int)CD45RA(Io)CD43(int)SIRP-alpha(int)CD4(-)CD8(-) major histocompatibility complex class II-negative surface phenotype. The pre-cDCs were not monocytes. Monocytes generated few cDCs in steady-state recipient mice. However, when transferred into mice with an inflammatory milieu dependent on granulocyte-macrophage colony-stimulating factor, monocytes produced a distinct type of splenic DC. Thus, the inflammatory status of the host influences the developmental origin and type of DC present in lymphoid tissues.

引用

页码：663 / 671

页数：9

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