Chromatin remodelling: the industrial revolution of DNA around histones

被引：433

作者：

Saha, Anjanabha

Wittmeyer, Jacqueline

Cairns, Bradley R.

机构：

[1] Univ Utah, Sch Med, Dept Oncol Sci, Huntsman Canc Inst, Salt Lake City, UT 84112 USA

[2] Univ Utah, Sch Med, Howard Hughes Med Inst, Huntsman Canc Inst, Salt Lake City, UT 84112 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 06期

关键词：

D O I：

10.1038/nrm1945

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chromatin remodellers are specialized multi-protein machines that enable access to nucleosomal DNA by altering the structure, composition and positioning of nucleosomes. All remodellers have a catalytic ATPase subunit that is similar to known DNA-translocating motor proteins, suggesting DNA translocation as a unifying aspect of their mechanism. Here, we explore the diversity and specialization of chromatin remodellers, discuss how nucleosome modifications regulate remodeller activity and consider a model for the exposure of nucleosomal DNA that involves the use of directional DNA translocation to pump 'DNA waves' around the nucleosome.

引用

收藏

页码：437 / 447

页数：11

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