Subcellular distribution of components of the ubiquitin-proteasome system in non-diseased human and rat brain

被引：24

作者：

Adori, C

Low, P

Moszkovkin, G

Bagdy, G

László, L

Kovács, GG

机构：

[1] Eotvos Lorand Univ, Dept Anat Cell & Dev Biol, H-1117 Budapest, Hungary

[2] Natl Inst Neurol & Psychiat, Dept Neuropathol, Budapest, Hungary

[3] Natl Inst Neurol & Psychiat, Lab Neurochem & Expt Med, Budapest, Hungary

来源：

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY | 2006年 / 54卷 / 02期

关键词：

ubiquitin; proteasome; regulatory ATPase; clastosome; brain; immunohistochemistry;

D O I：

10.1369/jhc.5B6752.2005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Our aim was to investigate and to compare the intracellular distribution of ubiquitin, 20S proteasome, and all six proteasomal regulatory ATPases in non-diseased human and rat brains. Ubiquitin and ATPases S4 and S7 show dominant nuclear immunostaining, whereas subunits S6a, S6b, and S10b show mainly cytoplasmic immunostaining in both species. However, S8 localization is inconsistent, prevailing nuclear in rat and cytoplasmic in human. In rat brain, small clastosome-like nuclear bodies demonstrate strong ubiquitin, 20S, and S6a immunoreactivity both in neurons and glial cells. Prominent nuclear immunolocalization of members of the ubiquitin-proteasome system provides morphological evidence for function of these proteins in transcription regulation and/or DNA repair.

引用

页码：263 / 267

页数：5

共 15 条

[1] The ubiquitin-proteasome system in Creutzfeld-Jakob and Alzheimer disease:: Intracellular redistribution of components correlates with neuronal vulnerability [J].