Gene-regulating protein kinases as important anti-inflammatory targets

被引:16
作者
Bhagwat, SS [1 ]
Manning, AM [1 ]
Hoekstra, MF [1 ]
Lewis, A [1 ]
机构
[1] Signal Pharmaceut, San Diego, CA 92121 USA
关键词
D O I
10.1016/S1359-6446(99)01402-6
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Protein phosphorylation is a key cellular regulatory mechanism. Protein kinases and phosphatases regulate cell-cycle progression, transcription, translation, protein sorting and cell adhesion events that are critical to the inflammatory process. Two of the best-characterized immunosuppressants, cyclosporin and rapamycin, are also effective anti-inflammatory drugs. They act directly on protein phosphorylation and, as such, validate the concept that small-molecule modulators of phosphorylation cascades possess antiinflammatory properties. The authors describe studies that outline progress in defining specific protein kinase signal-transduction cascades, the key drug discovery targets in these cascades and progress towards developing selective agents that have potential in treating numerous inflammatory diseases.
引用
收藏
页码:472 / 479
页数:8
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