High-throughput multiclass method for antibiotic residue analysis by liquid chromatography-tandem mass spectrometry

被引：89

作者：

Chico, J. ^{[1
]}

Rubies, A. ^{[2
]}

Centrich, F. ^{[2
]}

Companyo, R. ^{[1
]}

Prat, M. D. ^{[1
]}

Granados, M. ^{[1
]}

机构：

[1] Univ Barcelona, Fac Quim, Dept Quim Analit, E-08028 Barcelona, Spain

[2] Lab Agencia Salut Publ Barcelona, Area Analisi Organ, Serv Quim, Barcelona 08001, Spain

来源：

JOURNAL OF CHROMATOGRAPHY A | 2008年 / 1213卷 / 02期

关键词：

Food analysis; Sulfonamides; Quinolones; Penicillins; Tetracyclines; Macrolides; LC-MS/MS;

D O I：

10.1016/j.chroma.2008.10.023

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple and rapid method has been developed for the residue analysis of 39 antibiotics (tetracyclines, quinolones, penicillins, sulfonamides and macrolides) in foodstuffs of animal origin. The method combines an effective extraction technique, which uses water-methanol as extracting solvent, with ultra-high-pressure liquid chromatography-tandem mass spectrometry, allowing both confirmation and quantification in a single chromatographic run. The multiresidue method has been validated in chicken muscle matrix according to European Union Decision 2002/657/EC. It has been implemented as a routine method in a Public Health Laboratory, instead of the five plates test and LC methods previously used. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：189 / 199

页数：11

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