Protein inhibitor of neuronal nitric oxide synthase interacts with protein kinase A inhibitors

被引：10

作者：

Yu, JQ ^{[1
]}

Yu, L ^{[1
]}

Chen, Z ^{[1
]}

Zheng, LH ^{[1
]}

Chen, XS ^{[1
]}

Wang, X ^{[1
]}

Ren, DM ^{[1
]}

Zhao, SY ^{[1
]}

机构：

[1] Fudan Univ, Inst Genet, State Key Lab Genet Engn, Shanghai 200433, Peoples R China

来源：

MOLECULAR BRAIN RESEARCH | 2002年 / 99卷 / 02期

基金：

美国国家科学基金会;

关键词：

protein kinase A inhibitor; protein inhibitor of neuronal nitric oxide synthase; signal transduction; yeast two hybrid; co-immunoprecipitation;

D O I：

10.1016/S0169-328X(02)00104-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Protein kinase A (PKA) and neuronal nitric oxide synthase (nNOS) are important signaling molecules. It is well known that PKA can specifically phosphorylate nNOS. But the underlying molecular mechanism is still obscure. Our data indicate that the protein inhibitor of nNOS (PIN) binds to protein kinase A inhibitors (PKIs), which suggests that PKIs, together with PIN, might mediate the phosphorylation of nNOS by PKA. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：145 / 149

页数：5

共 15 条

[1]

BREDT DS, 1992, J BIOL CHEM, V267, P10976

[2] NITRIC-OXIDE - A PHYSIOLOGICAL MESSENGER MOLECULE [J].

BREDT, DS ;

SNYDER, SH .

ANNUAL REVIEW OF BIOCHEMISTRY, 1994, 63 :175-195

[3] PHOSPHORYLATION OF NITRIC-OXIDE SYNTHASE BY PROTEIN KINASE-A [J].

BRUNE, B ;

LAPETINA, EG .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 181 (02) :921-926

[4] Protein kinase A anchoring [J].

DellAcqua, ML ;

Scott, JD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (20) :12881-12884

[5] CYCLIC-NUCLEOTIDE DEPENDENT PHOSPHORYLATION OF NEURONAL NITRIC-OXIDE SYNTHASE INHIBITS CATALYTIC ACTIVITY [J].

DINERMAN, JL ;

STEINER, JP ;

DAWSON, TM ;

DAWSON, V ;

SNYDER, SH .

NEUROPHARMACOLOGY, 1994, 33 (11) :1245-1251

[6] AKAP79 and the evolution of the AKAP model [J].

Dodge, K ;

Scott, JD .

FEBS LETTERS, 2000, 476 (1-2) :58-61

[7]

FANTOZZI DA, 1994, J BIOL CHEM, V269, P2676

[8] Molecular glue: Kinase anchoring and scaffold proteins [J].

Faux, MC ;

Scott, JD .

CELL, 1996, 85 (01) :9-12

[9] PIN: An associated protein inhibitor of neuronal nitric oxide synthase [J].

Jaffrey, SR ;

Snyder, SH .

SCIENCE, 1996, 274 (5288) :774-777

[10] LOCALIZATION OF PROTEIN-KINASES BY ANCHORING PROTEINS - A THEME IN SIGNAL-TRANSDUCTION [J].

MOCHLYROSEN, D .

SCIENCE, 1995, 268 (5208) :247-251

← 1 2 →