Combinatorial synthesis of heterocycles:: Solid-phase synthesis of 2-amino-4(1H)-quinazolinone derivatives

被引：58

作者：

Gopalsamy, A ^{[1
]}

Yang, H ^{[1
]}

机构：

[1] Wyeth Ayerst Res, Div Chem Sci, Pearl River, NY 10965 USA

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2000年 / 2卷 / 04期

关键词：

D O I：

10.1021/cc000017d

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new solid-phase synthesis of various substituted 2-amino-4(1H)-quinazolinones from a resin bound amine component is described. The amine was readily converted to the corresponding polymer bound S-methylthiopseudourea. Condensation with different substituted isatoic anhydrides afforded 2-amino-4(1H)-quinazolinone derivatives. The method is amenable for combinatorial library generation.

引用

页码：378 / 381

页数：4

共 27 条

[1]

Andres CJ, 1999, COMB CHEM HIGH T SCR, V2, P191

[2]

[Anonymous], BIOORG MED CHEM LETT

[3] Solid-phase organic reactions III: A review of the literature Nov 96 Dec 97 [J].

Booth, S ;

Hermkens, PHH ;

Ottenheijm, HCJ ;

Rees, DC .

TETRAHEDRON, 1998, 54 (51) :15385-15443

[4] Solid-phase synthesis of 2,4,6-trisubstituted pyridines [J].

Chiu, CF ;

Tang, ZL ;

Ellingboe, JW .

JOURNAL OF COMBINATORIAL CHEMISTRY, 1999, 1 (01) :73-77

[5] CHEMISTRY OF 2H-3,1-BENZOXAZINE-2,4(1H)-DIONE (ISATOIC ANHYDRIDE) .2. REACTIONS WITH THIOPSEUDOUREAS AND CARBANIONS [J].

COPPOLA, GM ;

HARDTMANN, GE ;

PFISTER, OR .

JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (05) :825-831

[6]

COPPOLA GM, 1980, SYNTHESIS-STUTTGART, P505

[7] Recent progress in solid phase heterocycle syntheses. A review [J].

Corbett, JW .

ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 1998, 30 (05) :489-+

[8] DESIGN AND SYNTHESIS OF 2-(ARYLAMINO)-4(3H)-QUINAZOLINONES AS NOVEL INHIBITORS OF RAT LENS ALDOSE REDUCTASE [J].

DERUITER, J ;

BRUBAKER, AN ;

MILLEN, J ;

RILEY, TN .

JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (05) :627-629

[9] Design, synthesis, and evaluation of small-molecule libraries [J].

Ellman, JA .

ACCOUNTS OF CHEMICAL RESEARCH, 1996, 29 (03) :132-143

[10] Novel structural templates for estrogen-receptor ligands and prospects for combinatorial synthesis of estrogens [J].

Fink, BE ;

Mortensen, DS ;

Stauffer, SR ;

Aron, ZD ;

Katzenellenbogen, JA .

CHEMISTRY & BIOLOGY, 1999, 6 (04) :205-219

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