Combinatorial synthesis of heterocycles:: Solid-phase synthesis of 2-amino-4(1H)-quinazolinone derivatives

被引：58

作者：

Gopalsamy, A ^{[1
]}

Yang, H ^{[1
]}

机构：

[1] Wyeth Ayerst Res, Div Chem Sci, Pearl River, NY 10965 USA

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2000年 / 2卷 / 04期

关键词：

D O I：

10.1021/cc000017d

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new solid-phase synthesis of various substituted 2-amino-4(1H)-quinazolinones from a resin bound amine component is described. The amine was readily converted to the corresponding polymer bound S-methylthiopseudourea. Condensation with different substituted isatoic anhydrides afforded 2-amino-4(1H)-quinazolinone derivatives. The method is amenable for combinatorial library generation.

引用

页码：378 / 381

页数：4

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