Diastereoselective solid-phase synthesis of novel hydantoin- and isoxazoline-containing heterocycles

被引：43

作者：

Park, KH ^{[1
]}

Olmstead, MM ^{[1
]}

Kurth, MJ ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Chem, Livermore, CA 95616 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 19期

关键词：

D O I：

10.1021/jo9807161

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Exploiting 1,3-dipolar cycloaddition and carbanilide cyclization transformations, we have prepared novel spirocyclic isoxazoloimidazolidinedione heterocycles of generalized structures II and III on solid phase starting from Merrifield resin. Cyclopentanoid isoxazoloimidazolidinedione II was obtained with complete diastereoselectivity, and cyclopropanoid isoxazoloimidazolidinedione III was obtained as an approximate to 2:1 mixture of diastereomers.

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页码：6579 / 6585

页数：7

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