IB-96212, a novel cytotoxic macrolide produced by a marine Micromonospora -: I.: Taxonomy, fermentation, isolation and biological activities

被引：28

作者：

Fernández-Chimeno, RI ^{[1
]}

Cañedo, L ^{[1
]}

Espliego, F ^{[1
]}

Grávalos, D ^{[1
]}

De la Calle, F ^{[1
]}

Fernández-Puentes, JL ^{[1
]}

Romero, F ^{[1
]}

机构：

[1] PharmaMar, Drug Discovery Div, Madrid 28760, Spain

来源：

JOURNAL OF ANTIBIOTICS | 2000年 / 53卷 / 05期

关键词：

D O I：

10.7164/antibiotics.53.474

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel bioactive macrolide, IB-96212 has been isolated from the fermentation broth of a marine actinomycete, L-25-ES25-008. The strain belongs to the genus Micromonospora. The macrolide showed a very strong cytotoxic activity against P-388, and lower but significant activity against A-549, HT-29, and MEL-28 cell lines. We describe the isolation, taxonomy and fermentation of the producing strain as well as the isolation of IB-96212.

引用

页码：474 / 478

页数：5

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