IB-96212, a novel cytotoxic macrolide produced by a marine Micromonospora -: II.: Physico-chemical properties and structure determination

被引：27

作者：

Cañedo, LM ^{[1
]}

Puentes, JLF

Baz, JP

Huang, XH

Rinehart, KL

机构：

[1] Inst Biomar SA, Drug Discovery Div, Leon 24231, Spain

[2] Univ Illinois, Roger Adams Lab, Urbana, IL 61801 USA

来源：

JOURNAL OF ANTIBIOTICS | 2000年 / 53卷 / 05期

关键词：

D O I：

10.7164/antibiotics.53.479

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

IB-96212, is a new member of spiroketal containing macrolide class of fermentation-derived natural products isolated from mycelial extracts of Micromonospora sp. The structure consists of a new aglycone which possesses a 26-membered macrolide ring system and of one deoxy sugar identified as L-rhodinose, this structure represents the first reported spiroketal macrolide natural product related to other macrolides, such as oligomycins, dunaimycins, citovaricin, rutamycin and ossamycin.

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页码：479 / 483

页数：5

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