Discreet Charm of the GABAergic Bourgeoisie: Superconnected Cells Conduct Developmental Symphonies

被引:6
作者
Case, Marianne [1 ]
Soltesz, Ivan [1 ]
机构
[1] Univ Calif Irvine, Dept Anat & Neurobiol, Irvine, CA 92697 USA
关键词
NETWORKS; SYNCHRONY; DIVERSITY;
D O I
10.1016/j.neuron.2009.12.013
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
In an exciting study in the December 4(th) issue of Science, Bonifazi and colleagues demonstrated the existence and importance of exceedingly rare but unusually richly connected cells in the developing hippocampus. Manipulating the activity of single GABAergic hub cells modulated network activity patterns, demonstrating their importance for coordinating synchronous activity.
引用
收藏
页码:780 / 782
页数:3
相关论文
共 11 条
[1]
Emergence of scaling in random networks [J].
Barabási, AL ;
Albert, R .
SCIENCE, 1999, 286 (5439) :509-512
[2]
Developing networks play a similar melody [J].
Ben-Ari, Y .
TRENDS IN NEUROSCIENCES, 2001, 24 (06) :353-360
[3]
GABAergic Hub Neurons Orchestrate Synchrony in Developing Hippocampal Networks [J].
Bonifazi, P. ;
Goldin, M. ;
Picardo, M. A. ;
Jorquera, I. ;
Cattani, A. ;
Bianconi, G. ;
Represa, A. ;
Ben-Ari, Y. ;
Cossart, R. .
SCIENCE, 2009, 326 (5958) :1419-1424
[4]
Complex brain networks: graph theoretical analysis of structural and functional systems [J].
Bullmore, Edward T. ;
Sporns, Olaf .
NATURE REVIEWS NEUROSCIENCE, 2009, 10 (03) :186-198
[5]
Interneuron Diversity series:: Circuit complexity and axon wiring economy of cortical interneurons [J].
Buzsáki, G ;
Geisler, C ;
Henze, DA ;
Wang, XJ .
TRENDS IN NEUROSCIENCES, 2004, 27 (04) :186-193
[6]
A parturition-associated nonsynaptic coherent activity pattern in the developing hippocampus [J].
Crepel, Valerie ;
Aronov, Dmitriy ;
Jorquera, Isabel ;
Represa, Alfonso ;
Ben-Ari, Yehezkel ;
Cossart, Rosa .
NEURON, 2007, 54 (01) :105-120
[7]
Neuronal diversity and temporal dynamics: The unity of hippocampal circuit operations [J].
Klausberger, Thomas ;
Somogyi, Peter .
SCIENCE, 2008, 321 (5885) :53-57
[8]
Nonrandom connectivity of the epileptic dentate gyrus predicts a major role for neuronal hubs in seizures [J].
Morgan, Robert J. ;
Soltesz, Ivan .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (16) :6179-6184
[9]
High efficiency beam splitter for multifocal multiphoton microscopy [J].
Nielsen, T ;
Frick, M ;
Hellweg, D ;
Andresen, P .
JOURNAL OF MICROSCOPY-OXFORD, 2001, 201 :368-376
[10]
Highly nonrandom features of synaptic connectivity in local cortical circuits [J].
Song, S ;
Sjöstrom, PJ ;
Reigl, M ;
Nelson, S ;
Chklovskii, DB .
PLOS BIOLOGY, 2005, 3 (03) :507-519