Stimulus responsive elastin biopolymers: applications in medicine and biotechnology

被引：152

作者：

Chilkoti, Ashutosh ^{[1
]}

Christensen, Trine ^{[1
]}

MacKay, J. Andrew ^{[1
]}

机构：

[1] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2006年 / 10卷 / 06期

关键词：

INVERSE TEMPERATURE TRANSITION; FREE-ENERGY TRANSDUCTION; PROTEIN-BASED POLYMERS; CROSS-LINKING; TRIGGERED PURIFICATION; RECOMBINANT PROTEINS; DRUG-DELIVERY; IN-VITRO; POLYPEPTIDE; FUSION;

D O I：

10.1016/j.cbpa.2006.10.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Elastin-like polypeptides (ELPs) are artificial polypeptides, derived from Val-Pro-Gly-Xaa-Gly (VPGXG) pentapeptide repeats found in human tropoelastin, that reversibly coacervate above a critical temperature. Genetically encodable ELPs are monodisperse, stimuli responsive, and biocompatible, properties that make them attractive for drug delivery and tissue engineering. The potential of ELPs to self-assemble into nanostructures in response to environmental triggers is another interesting feature of these polypeptides that promises to lead to a host of new applications.

引用

页码：652 / 657

页数：6

共 56 条

[21] Overexpression of lysyl oxidase to increase matrix crosslinking and improve tissue strength in dermal wound healing [J].