Temporal MRI assessment of intracerebral hemorrhage in rats

被引:37
作者
Knight, Robert A. [1 ,4 ]
Han, Yuxia [2 ]
Nagaraja, Tavarekere N. [3 ]
Whitton, Polly [1 ]
Ding, Jennifer [2 ]
Chopp, Michael [1 ,4 ]
Seyfried, Donald M. [2 ]
机构
[1] Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA
[2] Henry Ford Hosp, Dept Neurosurg, Detroit, MI 48202 USA
[3] Henry Ford Hosp, Dept Anesthesiol, Detroit, MI 48202 USA
[4] Oakland Univ, Dept Phys, Rochester, MI USA
基金
美国国家卫生研究院;
关键词
edema; intracerebral hemorrhage; MRI;
D O I
10.1161/STROKEAHA.107.506683
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose - MRI was used to evaluate the effects of experimental intracerebral hemorrhage (ICH) on brain tissue injury and recovery. Methods - Primary ICH was induced in rats (n = 6) by direct infusion of autologous blood into the striatum. The evolution of ICH damage was assessed by MRI estimates of T(2) and T(1sat) relaxation times, cerebral blood flow, vascular permeability, and susceptibility-weighted imaging before surgery ( baseline) and at 2 hours and 1, 7, and 14 days post-ICH. Behavioral testing was done before and at 1, 7, and 14 days post-ICH. Animals were euthanized for histology at 14 days. Results - The MRI appearance of the hemorrhage and surrounding regions changed in a consistent manner over time. Two primary regions of interest were identified based on T2 values. These included a core, corresponding to the bulk of the hemorrhage, and an adjacent rim; both varied with time. The core was associated with significantly lower cerebral blood flow values at all post-ICH time points, whereas cerebral blood flow varied in the rim. Increases in vascular permeability were noted at 1, 7, and 14 days. Changes in T1sat were similar to those of T2. MRI and histological estimates of tissue loss were well correlated and showed approximately 9% hemispheric tissue loss. Conclusions - Although the cerebral blood flow changes observed with this ICH model may not exactly mimic the clinical situation, our results suggest that the evolution of ICH injury can be accurately characterized with MRI. These methods may be useful to evaluate therapeutic interventions after experimental ICH and eventually in humans.
引用
收藏
页码:2596 / 2602
页数:7
相关论文
共 42 条
  • [31] Improvement in neurological outcome after administration of atorvastatin following experimental intracerebral hemorrhage in rats
    Seyfried, D
    Han, YX
    Lu, DY
    Chen, JL
    Bydon, A
    Chopp, M
    [J]. JOURNAL OF NEUROSURGERY, 2004, 101 (01) : 104 - 107
  • [32] Acute hypertension in intracerebral hemorrhage: Pathophysiology and treatment
    Shah, Qasar A.
    Ezzeddine, Mustapha A.
    Qureshi, Adnan I.
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2007, 261 (1-2) : 74 - 79
  • [33] Reversible ischemia around intracerebral hemorrhage: a single-photon emission computerized tomography study
    Siddique, MS
    Fernandes, HM
    Wooldridge, TD
    Fenwick, JD
    Slomka, P
    Mendelow, AD
    [J]. JOURNAL OF NEUROSURGERY, 2002, 96 (04) : 736 - 741
  • [34] EXPERIMENTAL INTRACEREBRAL HEMORRHAGE - EFFECTS OF A TEMPORARY MASS LESION
    SINAR, EJ
    MENDELOW, AD
    GRAHAM, DI
    TEASDALE, GM
    [J]. JOURNAL OF NEUROSURGERY, 1987, 66 (04) : 568 - 576
  • [35] Mast cell blocking reduces brain edema and hematoma volume and improves outcome after experimental intracerebral hemorrhage
    Strbian, Daniel
    Tatlisumak, Turgut
    Ramadan, Usama Abo
    Lindsberg, Perttu J.
    [J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2007, 27 (04) : 795 - 802
  • [36] Quantitative perihematomal blood flow in spontaneous intracerebral hemorrhage predicts in-hospital functional outcome
    Tayal, Ashis H.
    Gupta, Rishi
    Yonas, Howard
    Jovin, Tudor
    Uchino, Ken
    Hammer, Maxim
    Wechsler, Lawrence
    Gebel, James M.
    [J]. STROKE, 2007, 38 (02) : 319 - 324
  • [37] Early metabolic alterations in edematous perihematomal brain regions following experimental intracerebral hemorrhage
    Wagner, KR
    Xi, GH
    Hua, Y
    Kleinholz, M
    De Courten-Myers, GM
    Myers, RE
    [J]. JOURNAL OF NEUROSURGERY, 1998, 88 (06) : 1058 - 1065
  • [38] MAGNETIC-RESONANCE-IMAGING OF PERFUSION USING SPIN INVERSION OF ARTERIAL WATER
    WILLIAMS, DS
    DETRE, JA
    LEIGH, JS
    KORETSKY, AP
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (01) : 212 - 216
  • [39] Pathophysiology of brain edema formation
    Xi, GH
    Keep, RF
    Hoff, JT
    [J]. NEUROSURGERY CLINICS OF NORTH AMERICA, 2002, 13 (03) : 371 - +
  • [40] Progression of mass effect after intracerebral hemorrhage
    Zazulia, AR
    Diringer, MN
    Derdeyn, CP
    Powers, WJ
    [J]. STROKE, 1999, 30 (06) : 1167 - 1173