The role of vascular endothelial growth factor in ossification

被引：201

作者：

Yang, Yan-Qi ^{[1
]}

Tan, Ying-Ying ^{[1
]}

Wong, Ricky ^{[1
]}

Wenden, Alex ^{[1
]}

Zhang, Lin-Kun ^{[1
,2
]}

Rabie, A. Bakr M.

机构：

[1] Univ Hong Kong, Dept Orthodont, Fac Dent, Hong Kong, Hong Kong, Peoples R China

[2] Nankai Univ, Dept Orthodont, Tianjin Stomatol Hosp, Tianjin 300071, Peoples R China

来源：

INTERNATIONAL JOURNAL OF ORAL SCIENCE | 2012年 / 4卷 / 02期

关键词：

endochondral ossification; intramembranous ossification; osteogenesis; vascular endothelial growth factor; HYPOXIA-INDUCIBLE FACTOR; MANDIBULAR CONDYLAR GROWTH; VEGF GENE-THERAPY; BONE-FORMATION; FACTOR EXPRESSION; GLENOID FOSSA; OSTEOCLAST DIFFERENTIATION; ENDOCHONDRAL OSSIFICATION; CHEMOTACTIC MIGRATION; ANGIOGENESIS;

D O I：

10.1038/ijos.2012.33

中图分类号：

R78 [口腔科学];

学科分类号：

100302 [口腔临床医学];

摘要：

Osteogenesis and angiogenesis are two closely correlated processes during bone growth, development, remodelling and repair. Vascular endothelial growth factor (VEGF) is an essential mediator during the process of angiogenesis. Based on an extensive literature search, which was carried out using the PubMed database and the keywords of osteogenesis, VEGF, endochondral ossification and intramembranous ossification, this manuscript reviews the role of VEGF in ossification, with emphasis on its effect in endochondral and intramembranous ossification. Osteogenesis and angiogenesis are closely correlated processes. VEGF acts as an essential mediator during these processes. It not only functions in bone angiogenesis but also in various aspects of bone development. International Journal of Oral Science (2012) 4, 64-68; doi:10.1038/ijos.2012.33; published online 22 June 2012

引用

页码：64 / 68

页数：5

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