Differential effects of vascular endothelial growth factor on joint formation during limb development

被引：1

作者：

Cortina-Ramirez, Gloria Emeli ^{[1
]}

Chimal-Monroy, Jesus ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City 04510, DF, Mexico

来源：

SKELETAL BIOLOGY AND MEDICINE, PT A: ASPECTS OF BONE MORPHOGENESIS AND REMODELING | 2007年 / 1116卷

关键词：

joint formation; cartilage; chondrocyte; digit development; VEGF; TGF-beta;

D O I：

10.1196/annals.1402.024

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

During skeletal development the proliferating chondrocytes choose between two fates: to differentiate into prejoint cells or undergo hypertrophy. Vascular endothelial growth factor (VEGF) participates in endochondral ossification, but it is unknown whether it has a role in joint development. We evaluated the VEGF effects on joints, implanting VEGF-beads in the presumptive limb joints of chick embryos. The wrist and elbow showed partial and complete fusions. Using the model of ectopic digits induced by transforming growth factor-beta (TGF-beta), VEGF inhibited joint formation when it was applied after TGF-beta. These data suggest differential effects of VEGF on different joints during development.

引用

页码：134 / 140

页数：7

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