The Versatility of the Helicobacter pylori Vacuolating Cytotoxin VacA in Signal Transduction and Molecular Crosstalk

被引：27

作者：

Backert, Steffen ^{[1
]}

Tegtmeyer, Nicole ^{[1
]}

机构：

[1] Natl Univ Ireland Univ Coll Dublin, Sch Biomol & Biomed Sci, Dublin 4, Ireland

来源：

TOXINS | 2010年 / 2卷 / 01期

关键词：

Helicobacter pylori; signalling; type IV secretion; CagA; pathogenicity island; vacuolating cytotoxin; VacA; lipid rafts; NF-KAPPA-B; EPITHELIAL-CELL MONOLAYERS; ANION-SELECTIVE CHANNELS; TOXIN VACA; IV SECRETION; EGF RECEPTOR; BINDING PROTEIN; LIPID-BILAYERS; RPTP-ALPHA; ACTIVATION;

D O I：

10.3390/toxins2010069

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

By modulating important properties of eukaryotic cells, many bacterial protein toxins highjack host signalling pathways to create a suitable niche for the pathogen to colonize and persist. Helicobacter pylori VacA is paradigm of pore-forming toxins which contributes to the pathogenesis of peptic ulceration. Several cellular receptors have been described for VacA, which exert different effects on epithelial and immune cells. The crystal structure of VacA p55 subunit might be important for elucidating details of receptor interaction and pore formation. Here we discuss the multiple signalling activities of this important toxin and the molecular crosstalk between VacA and other virulence factors.

引用

页码：69 / 92

页数：24

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