Receptor aggregation by intermembrane interactions: A Monte Carlo study

被引:8
作者
Fricke, GM
Thomas, JL [1 ]
机构
[1] Univ New Mexico, Dept Phys & Astron, Albuquerque, NM 87131 USA
[2] Univ New Mexico, Dept Comp Sci, Albuquerque, NM 87131 USA
关键词
Monte Carlo simulation; receptor aggregation; T cell; lattice model; phase separation;
D O I
10.1016/j.bpc.2005.09.019
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The lateral organization of receptors on cell surfaces is critically important to their function; many receptors transmit transmembrane signals when redistributed into clusters, while the response of others is potentiated by their aggregation. Cell-cell contact can play a crucial role in receptor aggregation, even when the bonds between receptors on one cell and ligands on the other are monovalent. Monte Carlo simulations on a two-membrane model were carried out to determine whether weak enthalpic interactions among receptors in one membrane, and among ligands in another, can work synergistically to give large-scale clustering when the two membranes are brought into contact. The simulations give support to such a clustering mechanism. In addition, because clustering is a cooperative process akin to a phase separation, individual receptors and ligands may undergo repeated binding and unbinding while in a clustered "phase," and a single ligand could interact with multiple different receptor partners. The results suggest a resolution of the dichotomy between serial triggering and aggregation models of T cell activation. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:205 / 211
页数:7
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