The synthesis of a combinatorial library using a tambjamine natural product template

被引：32

作者：

Davis, RA ^{[1
]}

Carroll, AR ^{[1
]}

Quinn, RJ ^{[1
]}

机构：

[1] Griffith Univ, AstraZeneca R&D, Brisbane, Qld 4111, Australia

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2001年 / 54卷 / 06期

关键词：

D O I：

10.1071/CH01123

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first demonstration of a parallel solution-phase synthesis using a tambjamine natural product template is reported. Isolation of the salts of tambjamines C (1), E (2) and F (3) from the Great Barrier Reef ascidian Sigillina signifera, followed by base hydrolysis, produced the known metabolite 4-methoxy-2-(1H-pyrrol-2'-yl)-1H-pyrrole-5-carbaldehyde (4). This aldehyde was subsequently used in a one-step synthesis to generate an enamine library. A simple liquid-liquid partitioning scheme was employed for purification and provided 10 tambjamine analogues in high purity.

引用

页码：355 / 359

页数：5

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