Human neuronal calcium sensor-1 shows the highest expression level in cerebral cortex

被引：17

作者：

Chen, CY ^{[1
]}

Yu, L ^{[1
]}

Zhang, PZ ^{[1
]}

Jiang, JM ^{[1
]}

Zhang, YZ ^{[1
]}

Chen, XS ^{[1
]}

Wu, Q ^{[1
]}

Wu, QH ^{[1
]}

Zhao, SY ^{[1
]}

机构：

[1] Fudan Univ, Sch Life Sci, Inst Genet, State Key Lab Genet Engn, Shanghai 200433, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2002年 / 319卷 / 02期

基金：

美国国家科学基金会;

关键词：

neuronal calcium sensors; gene cloning; gene expression pattern; human brain; cerebral cortex;

D O I：

10.1016/S0304-3940(01)02555-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuronal calcium sensors (NCS) are important constituents in the intracellular signaling pathways. A novel human gene, NCS-1, was identified in the present study. Among the 16 human tissues examined, NCS-1 is expressed most abundantly in the brain. Among the brain regions, the expression level of NCS-1 in cerebral cortex is the highest, which is about six times higher than the average level of the whole brain and a hundred times higher than the spinal cord. In the 12 different anatomical regions of human brain, the expression level of NCS-1 is very high in the temporal lobe, occipital pole, frontal lobe, thalamus, amygdala and hippocampus; moderate in cerebellum, putamen, caudate nucleus; low in the medulla, substantia nigra and the lowest in corpus callosum. Our results suggest that NCS-1 in human brain might be involved in a variety of brain functions such as sensory processing, motor control, emotional control, learning and memory. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：67 / 70

页数：4

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