Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia

被引：135

作者：

Spudich, A

Kilic, E

Xing, HY

Kilic, Ü

Rentsch, KM

Wunderli-Allenspach, H

Bassetti, CL

Hermann, DM

机构：

[1] Univ Zurich Hosp, Dept Neurol, CH-8091 Zurich, Switzerland

[2] Univ Zurich Hosp, Dept Clin Chem, CH-8091 Zurich, Switzerland

[3] Swiss Fed Inst Technol, Inst Pharmaceut Sci, CH-8093 Zurich, Switzerland

来源：

NATURE NEUROSCIENCE | 2006年 / 9卷 / 04期

关键词：

D O I：

10.1038/nn1676

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The blood-brain barrier possesses active transporters carrying brain-permeable xenobiotics back into the blood against concentration gradients. We demonstrate that multidrug resistance transporter (Mdr)-1 is upregulated on capillary endothelium after focal cerebral ischemia; moreover, Mdr-1 deactivation by pharmacological inhibition or genetic knockout preferably enhances the accumulation and efficacy of two neuroprotectants known as Mdr-1 substrates in the ischemic brain. We predict that Mdr-1 inhibition may greatly facilitate neuroprotective therapies.

引用

页码：487 / 488

页数：2

共 11 条

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