Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin

被引：41

作者：

Lipkowski, AW ^{[1
]}

Misicka, A

Davis, P

Stropova, D

Janders, J

Lachwa, M

Porreca, F

Yamamura, HI

Hruby, VJ

机构：

[1] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA

[2] Univ Arizona, Dept Pharmacol, Tucson, AZ 85721 USA

[3] Polish Acad Sci, Med Res Ctr, PL-02106 Warsaw, Poland

[4] Univ Warsaw, Dept Chem, PL-02093 Warsaw, Poland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(99)00464-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and biological activity of two fragments of the very potent opioid peptide biphalin, showed that Tyr-D-Ala-Gly-Phe-NH-NH<-Phe is the minimal fragment necessary to express equal affinities and the same biological activity profile as the parent biphalin. The replacement of N'-Phe with other L or D- lipophilic amino acids showed the possibility of modification of receptor efficacy of the analogues. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2763 / 2766

页数：4

共 9 条

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