The natural history of type 2 diabetes - Implications for clinical practice

被引：94

作者：

Ramlo-Halsted, BA ^{[1
]}

Edelman, SV ^{[1
]}

机构：

[1] Univ Calif San Diego, Div Endocrinol & Metab, San Diego, CA 92161 USA

来源：

PRIMARY CARE | 1999年 / 26卷 / 04期

关键词：

D O I：

10.1016/S0095-4543(05)70130-5

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This article reviews the natural history of type 2 diabetes and emphasizes that the disease is a continuum from impaired glucose tolerance and impaired fasting glucose to frank diabetes. Understanding this natural history aids the clinician in identifying those individuals most at risk for developing type 2 diabetes. Early intervention may significantly limit the severity of the microvascular and macrovascular complications of diabetes. Additionally, this article discusses oral antidiabetic agents and reviews their potential effectiveness at the different stages in the continuum to aid the clinician in developing a treatment strategy.

引用

页码：771 / +

页数：20

共 36 条

[1]

[Anonymous], 1995, NIH PUBL, P1

[2] Impaired glucose tolerance is normalized by treatment with the thiazolidinedione troglitazone [J].

Antonucci, T ;

Whitcomb, R ;

McLain, R ;

Lockwood, D .

DIABETES CARE, 1997, 20 (02) :188-193

[3] Prevalence of insulin resistance in metabolic disorders - The Bruneck Study [J].

Bonora, E ;

Kiechl, S ;

Willeit, J ;

Oberhollenzer, F ;

Egger, G ;

Targher, G ;

Alberiche, M ;

Bonadonna, RC ;

Muggeo, M .

DIABETES, 1998, 47 (10) :1643-1649

[4] EFFICACY OF METFORMIN IN PATIENTS WITH NON-INSULIN-DEPENDENT DIABETES-MELLITUS [J].

DEFRONZO, RA ;

GOODMAN, AM ;

ABELOVE, W ;

REID, E ;

PITA, J ;

CALLAHAN, M ;

JOHNSON, D ;

PELAYO, E ;

PUGH, J ;

SHANK, M ;

GARZA, P ;

HAAG, B ;

KORFF, J ;

ANGELO, A ;

IZENSTEIN, B ;

VANDERLEEDEN, M ;

CATHCART, H ;

TIERNEY, M ;

BIGGS, D ;

KARAM, J ;

NOLTE, M ;

GAVIN, L ;

ELDER, MA ;

CORBOY, J ;

THWAITE, D ;

WONG, S ;

DAVIDSON, M ;

PETERS, A ;

DUNCAN, T ;

KERCHER, S ;

FISCHER, J ;

KIPNES, M ;

RADNICK, BJ ;

ROURA, M ;

ROQUE, J ;

MONTGOMERY, C ;

COLLUM, P ;

RUST, M ;

POHL, S ;

PFEIFER, M ;

ALLWEISS, P ;

LEICHTER, S ;

LEACH, P ;

GALLINA, D ;

MUSEY, V ;

BERKOWITZ, K ;

EASTMAN, R ;

TAYLOR, T ;

DELAPENA, MS ;

ZAWADSKI, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (09) :541-549

[5]

*DIAB PREV PROGR R, 1998, PROT DIAB PREV PROGR

[6]

Draznin B, 1998, DIABETES, V47, pA85

[7]

EDELMAN SV, 1995, DIABETES, V16, P1

[8] Predictors of progression from impaired glucose tolerance to NIDDM - An analysis of six prospective studies [J].

Edelstein, SL ;

Knowler, WC ;

Bain, RP ;

Andres, R ;

BarrettConnor, EL ;

Dowse, GK ;

Haffner, SM ;

Pettitt, DJ ;

Sorkin, JD ;

Muller, DC ;

Collins, VR ;

Hamman, RF .

DIABETES, 1997, 46 (04) :701-710

[9] EARLY METABOLIC DEFECTS IN PERSONS AT INCREASED RISK FOR NON-INSULIN-DEPENDENT DIABETES-MELLITUS [J].

ERIKSSON, J ;

FRANSSILAKALLUNKI, A ;

EKSTRAND, A ;

SALORANTA, C ;

WIDEN, E ;

SCHALIN, C ;

GROOP, L .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (06) :337-343

[10] Poor physical fitness, and impaired early insulin response but late hyperinsulinaemia, as predictors of NIDDM in middle-aged Swedish men [J].

Eriksson, KF ;

Lindgarde, F .

DIABETOLOGIA, 1996, 39 (05) :573-579

← 1 2 3 4 →