The natural history of type 2 diabetes - Implications for clinical practice

被引:94
作者
Ramlo-Halsted, BA [1 ]
Edelman, SV [1 ]
机构
[1] Univ Calif San Diego, Div Endocrinol & Metab, San Diego, CA 92161 USA
来源
PRIMARY CARE | 1999年 / 26卷 / 04期
关键词
D O I
10.1016/S0095-4543(05)70130-5
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
This article reviews the natural history of type 2 diabetes and emphasizes that the disease is a continuum from impaired glucose tolerance and impaired fasting glucose to frank diabetes. Understanding this natural history aids the clinician in identifying those individuals most at risk for developing type 2 diabetes. Early intervention may significantly limit the severity of the microvascular and macrovascular complications of diabetes. Additionally, this article discusses oral antidiabetic agents and reviews their potential effectiveness at the different stages in the continuum to aid the clinician in developing a treatment strategy.
引用
收藏
页码:771 / +
页数:20
相关论文
共 36 条
[11]   PREVENTION OF TYPE-2 (NON-INSULIN-DEPENDENT) DIABETES-MELLITUS BY DIET AND PHYSICAL EXERCISE - THE 6-YEAR MALMO FEASIBILITY STUDY [J].
ERIKSSON, KF ;
LINDGARDE, F .
DIABETOLOGIA, 1991, 34 (12) :891-898
[12]  
Fagan Timothy C., 1998, American Journal of Medicine, V105, p77S, DOI 10.1016/S0002-9343(98)00216-2
[13]  
Gavin JR, 1997, DIABETES CARE, V20, P1183
[14]   CARDIOVASCULAR RISK-FACTORS IN CONFIRMED PREDIABETIC INDIVIDUALS - DOES THE CLOCK FOR CORONARY HEART-DISEASE START TICKING BEFORE THE ONSET OF CLINICAL DIABETES [J].
HAFFNER, SM ;
STERN, MP ;
HAZUDA, HP ;
MITCHELL, BD ;
PATTERSON, JK .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1990, 263 (21) :2893-2898
[15]   IMPAIRED GLUCOSE-TOLERANCE IN THE UNITED-STATES POPULATION [J].
HARRIS, MI .
DIABETES CARE, 1989, 12 (07) :464-474
[16]   PREVALENCE OF DIABETES AND IMPAIRED GLUCOSE-TOLERANCE AND PLASMA-GLUCOSE LEVELS IN UNITED-STATES POPULATION AGED 20-74 YR [J].
HARRIS, MI ;
HADDEN, WC ;
KNOWLER, WC ;
BENNETT, PH .
DIABETES, 1987, 36 (04) :523-534
[17]  
HARRIS MI, 1997, CONSULTANT S, V37, pS9
[18]   COMPARISON OF EFFICACY, SECONDARY FAILURE RATE, AND COMPLICATIONS OF SULFONYLUREAS [J].
HARROWER, ADB .
JOURNAL OF DIABETES AND ITS COMPLICATIONS, 1994, 8 (04) :201-203
[19]  
Henry Robert R., 1998, American Journal of Medicine, V105, p20S, DOI 10.1016/S0002-9343(98)00207-1
[20]   Troglitazone in combination with sulfonylurea restores glycemic control in patients with type 2 diabetes [J].
Horton, ES ;
Whitehouse, F ;
Ghazzi, MN ;
Venable, TC ;
Whitcomb, RW .
DIABETES CARE, 1998, 21 (09) :1462-1469