Enzyme-responsive supramolecular nanovalves crafted by mesoporous silica nanoparticles and choline-sulfonatocalix[4]arene [2]pseudorotaxanes for controlled cargo release

被引：131

作者：

Sun, Yu-Long ^{[1
]}

Zhou, Yue ^{[1
]}

Li, Qing-Lan ^{[1
]}

Yang, Ying-Wei ^{[1
]}

机构：

[1] Jilin Univ, State Key Lab Supramol Struct & Mat, Coll Chem, Changchun 130023, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 79期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

CONTROLLED DRUG-RELEASE; SULFONATOCALIXARENE; CALIXARENES; SYSTEM;

D O I：

10.1039/c3cc45216f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mesoporous silica nanoparticles (MSNs) have been surface-functionalized with choline moieties encircled by sulfonatocalix[4]arenes. Two enzyme cleavable sites are incorporated in the stalks for specific enzymes to regulate the release of loaded cargos from MSNs. These gated materials show a clear enzymatic response and proven orthogonality.

引用

页码：9033 / 9035

页数：3

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